Group Leader, Bioconjugation & Targeted RNA Delivery

Agency for Science, Technology and Research – Queenstown

Platform Technology, Full Time

About NATi

The Nucleic Acid Therapeutics Initiative (NATi), hosted by A

• STAR, is Singapore's national platform dedicated to advancing RNA-based medicines and revolutionizing drug and vaccine development. NATi's mission is to establish Singapore as a globally recognized hub of excellence in nucleic acid therapeutics research, clinical translation, and commercialization.

NATi focuses on key RNA modalities such as antisense oligonucleotides (ASOs), small interfering RNA (siRNA), and messenger RNA (mRNA). To drive this vision, NATi is building a biotech-like translational engine focused on asset and technology development spanning discovery to clinical development.

We are actively seeking passionate and committed RNA scientists with deep translational expertise to join us in advancing the next generation of RNA-based therapeutics.

Position Overview

We seek a highly innovative and results-driven scientific leader with deep expertise in bioconjugation and targeted delivery to pioneer ligand-oligonucleotide conjugates (LOCs) for extrahepatic RNA delivery. This role is instrumental in establishing scalable conjugation platforms and driving asset generation from discovery to translational development. The successful candidate will build a small group and establish an automated / scalable conjugation platform that can leverage diverse targeting ligands (e.g., small molecules, sugars, peptides, VHH, Fab, antibodies, lipids) to engineer LOCs that efficiently target skeletal / cardiac muscles, adipose tissues, and ocular compartments with high selectivity. The candidate will closely partner with oligonucleotide chemists, in vitro assay scientists, and in vivo pharmacologists to rapidly assess diverse conjugation approaches and linker chemistries to identify LOCs with optimized tissue- / cell-specific functional delivery, which is key for platform expansion and development of Drug Candidate(s).

Key Responsibilities

Qualifications & Experience

Global Recruitment & Competitive Compensation

NATi is conducting a global search for top-tier talent in RNA therapeutics. We welcome applications from leading pharmaceuticals scientists and biotech innovators worldwide.

This role provides a highly competitive compensation package aligned with global industry standards, including attractive benefits and long-term career growth opportunities within Singapore's thriving biomedical innovation ecosystem. Join us in shaping the future of RNA-based medicines and establishing Singapore as a world-class hub for nucleic acid therapeutics.

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