Scientist / Senior Scientist, RNA Analytical Development

Position Overview

We seek a highly innovative and results-driven scientific leader with deep expertise spanning multiple RNA modalities to establish the analytical development processes. This role is instrumental in establishing and executing phase-appropriate analytical strategies for raw materials (e.g., novel lipids, targeting ligands, pDNA), drug substances (DS) spanning mRNA and synthetic oligonucleotides (e.g., ASO, siRNA, gRNA), and drug products (DP) (e.g., conjugated oligonucleotides). The successful candidate will establish robust, scalable, and phase-appropriate analytical workflows to support platform scalability and pipeline programs. This role is critical to ensuring quality materials are developed and utilized across NATi’s translational programs.

Key Responsibilities

• Develop and execute a phase-appropriate analytical characterization strategy for raw materials (e.g., novel lipids, targeting ligands, pDNA), drug substances (e.g., mRNA, ASO, siRNA, gRNA), and drug products (e.g., LNP, conjugated oligonucleotides).
• Select and implement phase-appropriate analytical workflows for RNA raw materials, DS, DP using orthogonal techniques (e.g., HPLC, LC-MS, CE, UV spectroscopy, qPCR, DLS, TEM) to support platform development and pipeline programs.
• ApplyQuality by Design (QbD) principles to define critical quality attributes (CQAs) and ensure method robustness, scalability, and phase-appropriate throughput.
• Collaborate with cross-functional project teams to align analytical strategies with product development goals.
• Develop and maintain SOPs, method validation plans, and analytical documentation in compliance with industry standards and regulatory expectations.
• Maintain accurate records using LIMS / ELN systems to support data integrity and reproducibility.
• Prepare technical reports, presentations, and documentation to update project teams and stakeholders.
• Stay current with emerging analytical technologies and regulatory trends in RNA characterization.

Qualifications & Experience

Global Recruitment & Competitive Compensation

NATi is conducting a global search for top-tier talent in RNA therapeutics. We welcome applications from leading pharmaceutical scientists and biotech innovators worldwide. This role provides a highly competitive compensation package aligned with global industry standards, including attractive benefits and long-term career growth opportunities within Singapore's thriving biomedical innovation ecosystem. Join us in shaping the future of RNA-based medicines and establishing Singapore as a world-class hub for nucleic acid therapeutics.

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